Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration

Neurodegeneration is the progressive loss of structure or function neurons. Amyloid beta oligomers and aggregates have been linked to neurodegeneration. While previous studies suggested that dietary α-tocopherol intake can prevent amyloid aggregation protect brain against neurotoxicity, other research, however, indicated tocotrienol forms might be used as an alternate agent this kind degeneration. In presented we compared in vitro protective effects α-tocotrienol. context, formed neurodegeneration model with primary isolated neurons measured α-tocopherol's α-tocotrienol's effects. As a result, α-tocotrienol degeneration Moreover, regulated neuron's calcium channels mechanism by decreasing expression channel alpha 1C subunit. We also observed amount accumulation extracellular matrix decreased application these isoforms. specific time points, differ terms conclusion, it could interpreted that, more extended periods, significant beta-induced neurodegeneration, alternative agents, especially α-tocopherol.